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The phototoxicity of visible light, especially blue light, has been extensively studied

UV exposure induces the production of ROS, which subsequently activate the NF-B and MAPK signaling pathways, leading to increased transcription of pro-inflammatory cytokines (IL-1, TNF-, IL-6 and COX-2) and MMP-1, both of which contribute to inflammation and collagen degradation

copa-1(zu482) (2084, 3783)

Conclusion This study established a reliable letrozole-induced PCOS model in Wistar rats, effectively replicating key features of human PCOS, including hormonal imbalances, ovarian dysfunction, and metabolic disturbances

Independently of its antioxidant function, the compound has an anti-inflammatory role too, reducing the production of interleukines and the expression of TNF-alfa and iNOS synthase

Importantly, LLO alone was unable to permeabilize LUVs at 0 mol%, 10 mol% or 20 mol% CHOL, whereas it successfully permeabilized them when preincubated with Lm PC-PLC, achieving values similar to those obtained at 40 mol% of CHOL (Fig