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The augmented p21 expression, the increased phosphorylation of p53 at serine 15, and the decreased phosphorylation of retinoblastoma (Rb) at serine 780 have all been reported as markers for cell cycle arrest associated with senescence 30,31

10.1074/jbc.M601502200 39

doi: 10.3390/diseases13020059 446 VanVTHLiuZSHsiehYJShiuWCChenBYKuYWet al

Cureus 15:e34968

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material