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9, e1003436

doi: 10.1097/00004583-198811000-00010 [DOI] [PubMed] [Google Scholar] 428

5 Summary and future perspectives In summary, in the pathogenesis of DR, prolonged hyperglycemia affects the normal physiological function of RMCs, leading to the disturbances in the retinal water-ion balance, disruption of the BRB, imbalance in the homeostasis of the retinal microenvironment, and the secretion of pro-inflammatory cytokines and chemokines following RMCs overactivation

1 Introduction DNA methylation is a major covalent modification occurring at the C-5 position of cytosine in CpG dinucleotides, with cofactor S-adenosyl-l-methionine (SAM) as a methyl donor, which suppresses the transcription of the methylated gene (Costa et al., 2017)