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Apremilast also shows promise as maintenance therapy, preventing flare-ups after cyclosporine withdrawal and delaying the need for biologics

Science, 266, 439443

Schimmelfennig, 2020)

doi: 10.1038/s41589-021-00866-8 215 ZhangX.TianH.GuL.NieY.DingC.GeX.et al

For overweight or obese patients with knee osteoarthritis, intra-articular injection of PRP in a short time was not necessarily superior to hyaluronic acid, but long-term use was better than hyaluronic acid in pain and functional relief