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[4] The proposed mechanism of action, based only on preclinical animal studies, involves potential modulation of growth factor pathways, particularly vascular endothelial growth factor (VEGF), which may promote angiogenesisthe formation of new blood vessels

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As with any supplement, those with preexisting medical conditions or taking other medications should consult a healthcare professional before starting

Injection of local anaesthetic and steroids can be effective in management of piriformis syndrome