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Exp Clin Endocrinol Diabetes 105(02):109112 Okatani Y, Sagara Y (1995) Enhanced nocturnal melatonin secretion in women with functional secondary amenorrhea: relationship to opioid system and endogenous estrogen levels

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Taken together, these data showed that addition of N-glycan on N92 site of Ea-domain prevented the degradation of proIGF-1Ea by the proteasome, probably overcoming the folding limitation of Ea-domain and the tendency of unglycosylated proIGF-1Ea to self-aggregate