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Mol Oncol 6(5):516529

doi: 10.1200/JCO.23.00493 74 TaylorJWParikhMPhillipsJJJamesCDMolinaroAMButowskiNAet al

this linker is preferably of a length and sequence sufficient to ensure that each of the first and second domains can, independently from one another, retain their differential binding specificities

Importantly, the EWcp UCN1/CART-expressing neurons project to reward and addiction-related brain areas including the ventral tegmental area (VTA), dorsal raphe nucleus (DRN), central nucleus of amygdala (CeA) and the lateral septum (LS) 3

References 1.Ioannidis JPA

Specifically, neurons are post-mitotic cells that have a high metabolism and need high levels of oxygen that undergoes mitochondrial respiration, increasing ROS production