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Annu Rev Pharmacol Toxicol 62:255277

As a result, an accumulation of Lipid-OOH occurs: since GSH is the reducing co-substrate of GPX4, able to regulate the redox state of the cell-forming Lipid-OH (Figure 2A), GSH depletion can negatively regulate GPX4, triggering ferroptosis [19]

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Discussion It has been estimated that 30 million people in the United States are affected by type 2 diabetes mellitus (T2DM), with an additional 80 million in the early stage of pre-diabetes