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The expressions of two key glycolytic enzymes hexokinase II (HK-II) and pyruvate dehydrogenase kinase 2 (PKM2) are mediated by transcription factors hypoxia-inducible factor 1 (HIF-1) and tumor suppressor gene p53, respectively, and dysregulation of these two transcription factors by cigarette smoke [34, 35] represents a possible explanation for the enhanced glycolysis in CSE-treated NSCLC cells

So find out if there are any openings you can caulk or seal where the smoke or the odor it leaves behind might find its way into your dwelling

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Authored by : Theodor de Bry after John White

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