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As environmental factors, gut microbiota performs critical functions in the pathogenesis of AS through various mechanisms, including interacting with genes, enhancing intestinal permeability, activating the gut mucosa immune system, and affecting the intestinal microbiota metabolites

Abundant evidence shows that mitochondrial dysfunction, which can be induced by aging, genetics, and nutritional predispositions, plays a critical role in the pathogenesis of glaucoma.[7, 911, 14, 42] This includes not only focal, but also systemic mitochondrial dysfunction

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Glutathione supports mitochondrial function, so when reserves are stretched thin, cells simply have less energy to work with

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L-Glutathione L-Glutathione is a naturally occurring tripeptide composed of the amino acids cysteine, glutamic acid, and glycine