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5.1 Pharmacological agents SGLT2 inhibitors exemplify the most clinically validated metabolic therapy

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TDP-43 pathology was originally defined with the accumulation of proteins that include phosphorylated TDP-43 (pTDP-43) in the cytoplasm of neurons that undergo degeneration 10 , and this pathology was broadly observed in a wide spectrum of ALS cases 44

A 2019 review in the Journal of Translational Medicine synthesized evidence linking RDW with chronic inflammation and oxidative stress markers, supporting its use as a general stress signal beyond hematology

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As a synthetic peptide designed to significantly enhance cognitive functions, it represents a leap forward in therapeutic research