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While most clinical evidence supports a favorable safety profile at typical therapeutic doses, caution is warranted as higher doses may cause sedation, cardiovascular effects such as hypotension and arrhythmias, and, in rare cases, respiratory depression

For instance, overexpression of epidermal growth factor receptor ( EGFR ) is more common in lung cancer among never smokers (Pallis 2013a

Nrf2-deficient mice exposed to CS had more extensive emphysema and more pronounced airway inflammation than wild-type mice

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Patients were followed for 1 year with an initial assessment of the underlying liver disease with Fibroscan and thereafter visited every 3 months by the psychologist

Supplementary Figure S6B)