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Therefore, precise regulation of ROS generation and clearance is critical for maintaining cellular homeostasis

This SCFA-mediated reinforcement of intercellular junctions reduces the risk of increased intestinal permeability, commonly referred to as leaky gut, a pathological condition that enables the translocation of luminal antigens and other deleterious molecules into the systemic circulation (170)

The highest content of spermidine can be found in bean seeds, especially in soybeans, and in mushrooms, ranging approximately 100200 mg/kg

Acute extensive physical exertion often increases intestinal permeability which may be related to the induction of heat stress, that organisms cannot cope with at that time due to insufficient resources

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