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Under normal conditions, ROS levels are dynamically balanced by the antioxidant system in testicular tissue to meet the metabolic requirements of spermatogenic cells and to regulate male reproductive processes, including SSC renewal, proliferation and differentiation, maturation, and spermegg binding [48]

Distinguishing between the effects of increased HD dose (ie, urea reduction ratio [URR] or Kt/V) from effects of concomitant changes in membrane on response to ESA therapy is difficult because most studies compared different Kt/V levels using membranes of different types

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Angew Chem Int Ed Engl 60(6):31213130

It is a powerful tool for structured decision-making, not an objective arbiter of truth

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