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Accessed 19 Nov

Regulation of the Notch signaling pathway by natural products for cancer therapy

In the context of skin melanocytes, particularly cannabidiol (CBD) and cannabigerol (CBG) exert significant modulatory effects on the cellular redox state, primarily through antioxidant, receptor-mediated, and lipid-regulating mechanisms, which may influence melanoma development and oxidative stress mitigation 162,163,164

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Supporting these findings, a recent PET (positron emission tomography) imaging study by (Kato et al., 2023) demonstrated a significant reduction in Complex I availability in the anterior cingulate cortex of ASD individuals, reinforcing the hypothesis that compromised mitochondrial respiration plays a key role in ASD pathophysiology

In mice, preliminary studies demonstrated that failing hearts consumed higher amounts of ketone bodies than healthy hearts ( Recently, the current treatment of type 2 diabetes with inhibitors of tubular sodium/glucose cotransporter2 (GLT2i) highlighted other important roles played by KBs