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Sime, F., Penaloza, D

PLoS One 13 (11), e0206764

reduced glutathione, an important intracellular metabolite for regulation, is a prosthetic group of glyceraldehyde phosphate dehydrogenase, is a coenzyme of glyoxalase and triose dehydrogenase, participates in tricarboxylic acid cycle and sugar metabolism in vivo, and can activate various enzymes such as sulfhydryl (-SH) enzyme-coenzyme and the like, thereby promoting carbohydrate, fat and protein metabolism

The peroxynitrites stimulate the genetic expression of HO-1 in non-diabetic people, but in diabetics glucose suppresses the effects on the expression HO-1