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4 This is the same vagal circuit that Samsoms pramlintide study implicated: the gastric-emptying delay is a brain-to-stomach command relayed down the vagus, not a peptide throttling the pylorus directly

Additionally, psychological interventions like cognitive behavioral therapy and gut-directed hypnotherapy demonstrate robust effectiveness across symptom domains

All studies were approved by the University of Washington IACUC

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The mechanistic rationale for stacking MOTS-c 5-Amino-1MQ holds regardless of administration route, but practical bioavailability constraints may require adjustment