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The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes

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doi:10.1002/jso.24160

For example, ACLY is needed for the production of the eicosanoid prostaglandin E2 (PGE 2 ) in response to LPS or TNF- stimulation in phorbol-12-myristate-13-acetate (PMA)-differentiated U937 cells, human monocytic cells from histiocytoma 73

However, most of these nonspecific activators affect multiple target proteins in addition to SIRT1, and the specific downstream pathways through which SIRT1 protects the cochlea following noise exposure have not yet been fully elucidated

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