l-carnitine side effects fishy odor nausea diarrhea L-Carnitine: Benefits, Uses, and Acetyl-L-Carnitine Allergy: Symptoms and Treatment

Some of them were identified as variants of concern given their association with higher severity of COVID-19 disease

First, genetic alterations in mtDNA, including mtDNA point mutations, diabetes-related mtDNA polymorphisms, ethnicity-specific mtDNA haplogroups, and low mtDNA copy number, have been reported to be associated with defective insulin secretion, insulin resistance, or both [4-8]

Cells 2023;12, doi: Gonalves, S

9,10 Mitochondria, which are critical for cellular respiration and metabolism, suffer damage to their own mitochondrial DNA by the actions of reactive oxygen species and peroxynitrite compounds, and they have been directly implicated in the process leading to cessation of ATP synthesis

Ann Neurol 94:825835

Clinical profiling and screening for HNF4 and GCK gene mutations in Kashmiri patients with maturity-onset diabetes of the young (MODY)