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RSL3 drives ferroptosis through GPX4 inactivation and ROS production in colorectal cancer

133, jcs237453

Like the previously described radiation-induced lung and skin fibrosis, TGF-1 and CTGF are involved in the regulation of cardiac fibrosis [230]

ROS then activates MAPK cascadeMAP3K such as apoptosis signal-regulating kinase 1 (ASK1) which activates MAP2K such as MAP2K 4 (MKK4) which then activates JNK