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Of the 7 clinical studies, four were randomized controlled trials (RCTs), two were open-label trials, and one was a follow-up case series

Cystathionine beta-synthase is enriched in the brains of Downs patients

Under As stress, Si supplementation dramatically boosts the activities of key antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), peroxidase (POD) and glutathione reductase (GR), as well as important non-enzymatic antioxidants like cysteine, ascorbic acid (AsA), and glutathione (GSH)

However, more recent studies have reported contradictory findings such as no significant reduction in the growth of HCT116, DLD1 or CT26 grafts under an SD diet 115,153,154

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