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In the context of MS, there is a suggestion that heightened angiogenesis plays a role in both disease progression and remission following relapse (Korn 2008

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In the metabolism of aromatic amines, N-hydroxy aromatic amine metabolites generated in the liver enter the bladder via urine and are further acetylated by NAT1 in the bladder epithelial cells, resulting in the production of highly reactive intermediates