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Nrf2-ARE, as an important pathway of ferroptosis, reduces the expression of free iron and smooth muscle actin by up-regulating the expression of HO-1, reduces collagen fiber synthesis, and finally inhibits ferroptosis-related pulmonary fibrosis (133)

Louis School of Medicine, USA Copyright 2015 Grunwell, Gillespie, Ward, Fitzpatrick, Brown, Gauthier and Hebbar

Proceedings of the National Academy of Sciences of the United States of America 91:4731-4735

doi: 10.1111/j.1365-2125.1981.tb01193.x

it is perfectly intact in mice after depletion of subcapsular sinus macrophages

Some areas have soils richer in cobalt and may not need to require therapeutic feeding