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Nevertheless, even small proteins, such as Trx and glutaredoxin can similarly function as thiol antioxidants, showing redox-active mono- or di-cysteine motif (CXXC)

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This frees NF-B to translocate into the nucleus, where it triggers the transcription of over 400 genes linked to inflammation, including pro-inflammatory cytokines like TNF-, IL-1, and IL-6

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2012) and optimization of targeting signal peptides (Karyolaimos et al