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Epitalon remains a research compound worldwide, not approved by the FDA or equivalent regulatory agencies for medical treatment

The development of the CSCs theory The discovery and controversy of the CSCs As early as 1855, the work of pathologist Rudolph Virchow illuminated that tumors stem from existing normal cells, sparking a scientific discourse about the origin of tumors (Fig

All transcriptomic analysesincluding quality control, read alignment, gene quantification (TPM, FPKM, and raw counts), differential expression analysis, and pathway enrichment analyseswere conducted using the processed data provided by the sequencing center

an autophagosome must be formed, enclosing the mitochondria, which then fuses with the lysosome