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Chronic stress is another major factor, as elevated cortisol levels can suppress the immune system's ability to self-regulate

GSH cannot be administered directly because two pharmaceutical problems have been observed: poor bioavailability with oral administration, and a short half-life (2 min) with intravenous administration [54]

Most retinal optogenetics approaches depend on blue light irradiation to activate the photoswitch, during which relatively strong phototoxicity may damage corneal and retinal tissues

doi: 10.1038/s41580-018-0050-x

Symptoms such as nausea, diarrhea, or stomach cramps may occur, especially if taken on an empty stomach or in higher-than-recommended doses

Bull Exp Biol Med 135:590592