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Description

Over expression of cytochrome P450-sensitized hepatocyte to TNF-mediated cell death was associated with increased LPO and GSH depletion [166]

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GPX4 is an essential protective gene that systematic GPX4 knockout is embryonic lethal in mice [46]

IR can induce ferroptosis in intestinal tissue by increasing ACSL4 expression [39], decreasing GPX4 expression and activity [39, 44] and manipulating iron homeostasis to a pro-ferroptotic state [44, 52]