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Base editors further expand this toolbox by coupling catalytically inactive Cas enzymes with nucleotide-modifying domains, enabling precise correction without DNA breaks [188]

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In the context of wound healing, a comparable principle is the recycling of metabolites within the wound milieu immune cells and fibroblasts exchange arginine, ornithine, and citrullin e: for instance, activated macrophages metabolize arginine to ornithine via arginase to promote tissue repair, and neighboring fibroblasts can uptake ornithine to produce proline for collagen or convert it back to arginine if needed [48]