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In patients with progressive disease (significant fibrosis, chronic cholestasis, and portal hypertension), steroid treatment has not been shown to have beneficial effects.16 Ursodeoxycholic acid Ursodeoxycholic acid decreases biliary secretion of cholic and chenodeoxycholic acid, and inhibits the intestinal absorption of bile salt

However, it might influence physiological properties of the protein

[26] Rebouche CJ.Ann N Y Acad Sci

Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration

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