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Second-line treatments have also been designed over the past few years, including regorafenib (antiangiogenesis) (Bruix et al., 2017), nivolumab [against the programed cell death-1 (PD1) immune checkpoint] (El-Khoueiry et al., 2017), and ramucirumab (against VEGFR2) (Zhu et al., 2019)

Khalifa, A.N

Koak M, Akil E

6871 In addition, cancer associated fibroblasts participate in creating lipid-rich TME by secretion of free PUFAs that are incorporated into phospholipids of tumor cell membranes by ACSL4, which is highly expressed in many tumors, rendering them sensitive to ferroptosis

Mol Cell Oncol 4:e1302906 Dangol S, Chen Y, Hwang BK, Jwa NS (2019) Iron- and reactive oxygen species-dependent ferroptotic cell death in rice- Magnaporthe oryzae interactions