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Similarly, in hypertensive adults, elevated B 12 levels were linked to higher all-cause and cardiovascular mortality during hospitalization

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A aggregation leads to significant changes in the transcriptome, proteome, and metabolome of neurons

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hence, the metabolic features of NETosis initiation are aligned with those of neutrophil activation, including upregulation of glycolysis, lipid metabolism, and respiratory burst ( Figure 3 )

In vitro studies demonstrated that verapamil, when combined with rifapentine, enhanced antimicrobial activity against M.tb in macrophages [85]