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Executive function is improved in 90% of children things like awareness, cognition, appropriateness, eye contact when called, and just being more like a normal kid. Speech and language is improved in 80% of children all phases including spontaneous language, more complex sentences, increased vocabulary, etc

Preclinical studies found that treating neuronal, nematode, or rodent AD models with NR resulted in induction of a mitochondrial stress response, including UPR mt and mitophagy, reduced proteotoxic stress, and decreased A accumulation 243

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thus, the altered protein can only enter the vacuole via the non-selective autophagy pathway 31