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Although current data support the notion that HDACi overcomes resistance through epigenetic regulation and inhibition of pro-survival pathways, the limitations of small sample sizes and non-randomized designs necessitate validation through larger-scale studies (102)

doi: Smith KJ, Kapoor R, Felts PA (1999) Demyelination: the role of reactive oxygen and nitrogen species

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The human evidence is positive but more limited in scale than the prescription standards of care (minoxidil and 5-AR inhibitors), which have decades of large randomized controlled trials behind them

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