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5 Hypertension treatment: old friends and new players 5.1 Overview of antihypertensive therapies In clinical practice, the role of antihypertensive drugs that serve to improve endothelial dysfunction is crucial and enacted through multiple mechanisms, such as counteracting aortic stiffness, oxidative stress, inflammation, EndoMT, and altered vascular tone (88)

For example, IGF-1 overexpression in liver increases BW, lean mass, and body length (41), and IGF-1 overexpression in muscle or heart leads to hypertrophy and localized regeneration (4345)

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For example, thiolate can nucleophilically attack hydropersulfide to form disulfide and release hydrogen sulfide (H 2 S), which is similar to the reaction of thiolate with sulfenic acid or hydroperoxide (Switzer, 2023)

Figure 3 Implications for Therapeutic Interventions Because presbycusis is a predictable form of hearing loss and occurs over a long span of time, the therapeutic intervention for its prevention is feasible

When a compound is sprayed into the nose, it can pass through thin nasal membranes straight into local blood vessels