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Hypoxia-inducible factor 1 alpha (HIF-1 alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions - Its stabilization by hypoxia depends on redox-induced changes

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252 These findings highlight YTHDF3 as a key factor in the regulation of cancer development and progression, underscoring its potential as a therapeutic target

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Compound A induces IL-1 activation in myeloid cells via direct Caspase-8-mediated proteolysis and triggering of NLRP3 inflammasome activity 29,35

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