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doi:10.1001/jamanetworkopen.2022.36131 Mills EG, et al

When MRI does not clearly show the cause of trigeminal neuralgia, the most important step is to analyze how the pain behaves

Medications and previous treatments Long-term use of pain medications , repeated ineffective treatments, or certain drugs (such as statins in some patients , which may be associated with muscle-related symptoms ) may alter pain perception or contribute to persistent symptoms without resolving the underlying mechanism