GBM cells exhibit dysregulated iron metabolism (transferrin receptor overexpression, impaired iron efflux) and altered lipid metabolism (changes in desaturase activity, membrane phospholipid remodeling), conferring heightened ferroptosis susceptibility compared to normal neural cells [10]
Comparative analysis of gut microbiota composition across experimental groups Taxonomic shifts at genus and phylum levels based on DESeq2 analysis (Figure S2A-D): (1) Control vs
After 6 hours of incubation in 50 g/ml GO, we detected increased numbers of both autophagosomes and light spots
Favaro E, Carpanetto A, Caorsi C, Giovarelli M, Angelini C, Cavallo-Perin P, et al
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Furthermore, intracellular iron overload can be induced by certain exogenous substances that contain iron (such as heme chloride, FeCl 2 , and (NH 4 ) 2 Fe(SO 4 ) 2 ), leading to the effective initiation of ferroptosis