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This effect of AMPK signaling is in agreement with our previous studies showing that, despite having 15% and 40% of WT total and mitochondrial GSH levels (respectively), livers from nave GCLM KO mice maintain structural and functional integrity of the mitochondria and show induction of ER stress-related genes 17,38

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The antioxidant defense systems in the aged and those suffering from chronic degenerative disease especially those associated with inflammatory or autoimmune disease has been demonstrated to be weakened [7, 8]

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