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However, there was no overall improvement in depression symptoms, pain scores or in the results of a 12-item short form health survey

We are presenting it as the clinical pattern we have seen, with the appropriate caveats that clinical observation is subject to selection bias and confounding

You get vitamin B12 in your diet primarily by eating animal products and fortified foods

Convenience, Frequency, And Cost Injections Require syringes, safe disposal, and usually medical supervision Often weekly or monthly, depending on protocol Costs can add up with repeated clinic visits Nasal spray Takes a few seconds, wherever you are Easy to build into a daily routine No sharps, no office visit, and generally lower ongoing cost For many busy professionals, athletes, and biohackers, nasal sprays offer most of the benefits of injections with a lower barrier to consistent use

MOTS-c, a mitochondrial-derived peptide, has been studied for its role in AMPK-dependent metabolic regulation (Lee et al., 2015, Cell Metabolism)

B12 is found in animal products, so it can be difficult for vegans to get enough of this vitamin