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Alternatively, glutathione reductase (GR) recycles oxidized glutathione (GSSG) back to GSH in an NADPH-dependent manner 31

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Some researchers developed integer linear programming (ILP) approaches to infer cell-specific signaling pathways and predict the drug treatment effects ( Construction of a generic redox-regulated pathway map for SCC-61 and rSCC-61 cells The information obtained from four datasets (proteomics ( Supplementary Datasets S1S3 and Figures S1S3 ) was used to build a redox-regulated generic network of integrated signaling and metabolic subnetworks ( Figure 1 , and Figure S4 ) as detailed in the Supplementary Material

In these studies, OTA induced tissue-specific responses identified in kidney versus liver