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Most cytotoxics generate excess reactive oxygen species (ROS) either directly (radiolysis of water, redox cycling of platinum) or indirectly by impairing antioxidant enzymes [71, 72]

AT1R blocker losartan attenuates intestinal epithelial cell apoptosis in a mouse model of Crohns disease

Sakai Y, Suzuki A, Mugishima K, Sumi Y, Otsuka Y, Otsuka T, Ohno D, Murasawa T, Tsuruoka S (2014) Effects of alogliptin in chronic kidney disease patients with type 2 diabetes