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Hypothalamic AMP-activated protein kinase as a whole-body energy sensor and regulator

BDNF Upregulation One of the most well-characterized mechanisms involves upregulation of brain-derived neurotrophic factor (BDNF), the most abundant and important neurotrophin in the central nervous system that supports neuronal survival, growth, differentiation, synaptic plasticity, and cognitive function

From a therapeutic point of view, these strategies suffer from the problem how to administrate these molecules to receive an efficient uptake in the tumour cells

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An APOE-dependent molecular signature is commonly observed in AD-associated microglia

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