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A double-blind, placebo-controlled study published in the Journal of Pakistan Association of Dermatologists found that 1,200 mg of intravenous glutathione administered twice a week for 6 weeks resulted in visible skin tone lightening in 37.5% of participants

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Kalantar-Zadeh K, Jafar TH, Nitsch D, Neuen BL, Perkovic V

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Kwon DH, Lee H, Park C, Hong SH, Kim GY, Cha HJ, Kim S, Kim HS, Hwang HJ, Choi YH (2019) Glutathione induced immune-stimulatory activity by promoting M1-like macrophages polarization via potential ROS scavenging capacity