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Int J Biol Macromol Molecular basis of BACE1 modulation revealed by machine learning, molecular simulations, and experimental validation

Use of OHB as an efficient neurotherapeutic relies on increasing blood OHB levels so as to encourage entry of OHB to the brain

& Wittig, I

Results The results indicate that the combination treatment led to a significant reduction in body weight and improvements in hyperglycemia, dyslipidemia, and insulin resistance

Identification of the key residues responsible for the assembly of selenodeiodinases

ROS are produced in mitochondria (mainly via the electron transport chain, where ~12% of O 2 is reduced to form superoxide anions), peroxisomes (through the -oxidation of fatty acids) and the endoplasmic reticulum (through the oxidation of proteins)