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That single fact drives everything about how its administered

Unknown long-term effects : There is no long-term safety data for either compound used individually in the general population, let alone in combination

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These cardiovascular benefits may reduce the risk of heart disease, stroke, and other cardiovascular complications associated with obesity and metabolic dysfunction

Therefore, it is possible that NNMT may regulate energy metabolism through other mechanisms, and that NAD + is not necessary for this regulatory process

A common research framing is a defined block (often 812 weeks) followed by an off period, rather than indefinite continuous use a conservative default given the absence of long-term human data