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Furthermore, this improvement was not dependent on the optimization algorithm, as it consistently outperformed the t -statistic-ranked panel when fractions were evaluated using two other optimization methods (Constrained Projection 9 and Support Vector Regression 31 ) (SI Fig

H3K27ac is a histone modification associated with active chromatin, typically found at active enhancers and promoters, indicating potential transcriptional activation

The authors would like to thank Matthew Ingalls for helpful discussions and Jomy J

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Andreassi MG (2009) Metabolic syndrome, diabetes and atherosclerosis: influence of gene-environment interaction

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