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The juxtamembrane region, especially the phosphorylated tyrosine at position 972 in the NPEY motif of IR has been shown to be important for IRS and Shc recruitment 22,23

Background of Mitochondrial Biology and Leigh Syndrome Basics of Mitochondria Mitochondria are key organelles that are critical to normal cell and organ function and serve an essential role in maintaining metabolic homeostasis through the production of energy in the form of Adenosine Triphosphate (ATP) (Graeber and Muller, 1998

Blood (2015 ASH Annual Meeting Abstracts) 126(3704), 2015

10.1039/9781849732666-00247 13 CoccoR.StenbergG.DraganiB.PrincipeD

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Moltrasio, C., Romagnuolo, M