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You want to be sure your body is prepared to handle that die-off

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Silymarin was found to have hepatoprotective properties by scavenging free radical enzymes, reducing pro-inflammatory cytokines, stabilising cell membranes and promoting liver cell regeneration

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If you can't find the local guidelines online, best bet is probably to submit a FOI (Freedom of Information) request to your ICB/Health board asking which B12 deficiency guidelines they are using and for a link to or copy of them