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Nutrient deficiency and/or the stress of toxicity can cause mental disturbances according to the orthomolecular model

The resulting state of imbalance, known as oxidative stress, results in free radicals targeting cellular organelles, damaging lipids, nucleic acids, and proteins

Fundamentally, the occurrence and progression of chronic neurodegenerative diseases result from the interactions of multiple underlying mechanisms, necessitating multifaceted and multi-targeted therapeutic approaches

Alternatively the dual acquisition might have a biological origin e.g., challenge by a common parasite or infectious agent

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