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The present study supports these findings, as we show that an increased kynurenine/tryptophan (Kyn/Trp) ratio, a well-established marker of inflammation [63, 78, 79], correlates with manifest disease

Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia

Concurrently, SFN has been shown to improve anxiety and depression symptoms in mice by activating the Nrf2/ heme oxygenase-1 (HO-1) signaling pathway (Ferreira-Chamorro et al., 2018) and inhibiting the hypothalamicpituitaryadrenal (HPA) axis and stress response (Wu et al., 2016)

(59) investigated the effect of anxiety and depression symptoms on oxidative stress in AA patients

Meta-analyses published between 2022 and 2024 consistently report an 1824% elevation in lung cancer incidence among smokers receiving -carotene supplements, a finding corroborated by large-scale trials such as ATBC and CARET (246)

While this side effect is pretty rare, it can be extremely dangerous when left untreated